Mechanisms of Innate Immunity in Sepsis
نویسندگان
چکیده
The pathogenesis of the sepsis syndrome is critically dependent on activation of the innate immune response. Innate immunity plays a direct role in the development of sepsis and is also crucial for the activation and modulation of later antigen-specifi c adaptive immune responses. Nearly all of the clinical manifestations of sepsis and the systemic infl ammatory response syndrome (SIRS) can be attributed to components of the innate immune response. However, this review focuses on the new and expanding fi eld of innate immune activation by pathogen-responsive receptors, most importantly, the toll-like receptors (TLRs).
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